Today / Archive
The Daily Edition
Thursday, May 7, 2026
The Index
◈ Science Lightning Looks More Like a Particle Accelerator Every Year 10 min
⬡ AI Vibe Coding and Agentic Engineering Are Getting Closer Than I'd Like 5 min
◉ Wildcard For Every Patient Their Own Drug 20 min
◈ Science
Lightning Looks More Like a Particle Accelerator Every Year
Quanta Magazine · Charlie Wood · ~10 min read

Lightning still isn't solved. NASA's ALOFT aircraft campaign found gamma-ray flicker patterns matching Joseph Dwyer's runaway-electron avalanche theory, and a 2025 result from Xuan-Min Shao argues cosmic-ray showers may seed strikes by ionizing cloud particles at unexpected angles. The physics inside a thundercloud now looks closer to a particle collider than to a Franklin-era spark.

Read on Quanta Magazine →

⬡ AI & Product
Vibe Coding and Agentic Engineering Are Getting Closer Than I'd Like
Simon Willison's Weblog · Simon Willison · ~5 min read

Willison spent the year drawing a clean line between 'vibe coding' (no review, no responsibility) and 'agentic engineering' (ship with care). Now he admits the line is dissolving in his own practice — he's pushing agent output to production unreviewed because the success rate makes it feel reasonable. A short, candid piece about normalization of deviance happening in real time, from someone with the standing to notice it in himself.

Read on Simon Willison's Weblog →

◉ Medicine
For Every Patient Their Own Drug
Nautilus · Brady Huggett · ~20 min read

At 81, Stan Crooke — the man who built Ionis into the antisense-oligonucleotide company — is running a nonprofit that designs custom drugs for patients whose mutations affect fewer than 30 people on Earth. Huggett's profile of n-Lorem is also a quiet argument that the regulatory and economic frameworks for n-of-1 medicine have finally cracked open: 50 patients treated, 400 applications in. The first patient, Susannah, walked again.

Read on Nautilus →

The Rabbit Hole
Code w/ Claude 2026: The Live Blog

Anthropic's developer conference yesterday. The most architecturally interesting announcement: Managed Agents that 'dream' between sessions — a scheduled process where the agent reviews past runs, extracts patterns it missed in flight, and writes them to long-term memory. Also Code Review, Remote Agents (drive your laptop from your phone), and an 'advisor strategy' where smaller models consult Opus for frontier-level quality at a fraction of the cost. Willison's blog is the cleanest summary, skepticism about the SpaceX/Colossus compute deal intact.

Curated for one. Published for practice.
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